Amgen Scientist - Biologics in Thousand Oaks, California

Biologics Optimization is seeking a highly motivated Scientist to join the Protein Engineering group at our state-of-the-art research facility at the Amgen headquarters in Thousand Oaks, CA. The Biologics Optimization group is responsible for the optimization, production, assessment, and selection of large therapeutic drug candidates, with many of the molecules of interest being complex biologics.

The Protein Engineering group is responsible for the design and generation of novel and complex scaffold molecules, often antibody-based, that are part of the next generation of the large molecules therapeutics. The scientist will be a part of a multidisciplinary team with capabilities in protein engineering, cloning, expression, purification and characterization of large molecule drug candidate.


Drive protein design/engineering and molecular cloning of novel biologics molecules.

Act as a scientific leader with the ability to drive innovation, lead projects and teams, solve complex technical problems, and work independently and in cross-functional teams.

Develop and implement innovative technologies to improve efficiency and speed of the processes in the biologics optimization organization.

Provide scientific results that support the generation of publications, patents, or regulatory submissions, and participate in internal and external scientific meetings.

Basic Qualifications:

Doctorate degree


Master's degree and 4 years of scientific experience


Bachelor's degree and 6 years of scientific experience

Preferred Qualifications:

A strong track record of research accomplishments in protein design and protein engineering

Experience in laboratory techniques supporting structural biology and molecular biology

Familiar with one or more structural modeling programs such as Pymol, Chimera, MOE, Schrodinger, Rosetta and etc

Understanding of protein biophysical and biochemical properties that relate to molecule stability

Strong communication and interpersonal skills, and the ability to work flexibly in a dynamic and collaborative environment

Demonstrated a strong track record of independent critical thinking and scientific achievement in research, exemplified by publications in highly regarded journals, conference presentations or generation of intellectual property

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.