Amgen Pilot Plant - Manager, Downstream in Thousand Oaks, California

We are seeking a Manager for the Pilot Plant (based in Thousand Oak, CA) working in the Downstream team. This position will execute a variety of production-related operations in a large scale pilot plant, including but not limited to: performing processing on the floor (purification of Drug Substance); performing supporting activities such as buffer preparation, and equipment set-up/cleaning, execution of downstream operations, and managing staff. Work will also include executing production runs, experiments, commercial program support, and characterization efforts. Additional activities will include defining & documenting operation practices, ensuring documentation accurately reflects operations performed, developing and implementing area improvements (efficiency and safety) and lean principles, commissioning equipment, and participating in operations meetings.

The Thousand Oaks Pilot Plant performs frequent piloting of novel process operations (focusing primarily on large molecule cell culture and purification operations), driving technology development, supporting innovation across Amgen's entire spectrum, as well as executing non-GMP and pre-pivotal GMP bioprocessing operations for multiple mammalian and microbial products in order to develop & demonstrate production processes and produce bulk material. We produce sound, relevant data for the processes Amgen developments at meaningful scales that enable the rapid, successful transfer of our output to more dedicated manufacturing spaces. The environment is challenging, fast-paced and ever-changing with varying degrees of process definition, but very rewarding for those that like hands-on science and want to make process improvements in a development space.

Basic Qualifications

Doctorate degree OR

Master's degree and 3 years of Manufacturing and Operations experience OR

Bachelor's degree and 5 years of Manufacturing and Operations experience OR

Associate's degree and 10 years of Manufacturing and Operations experience OR

High school diploma / GED and 12 years of Manufacturing and Operations experience AND

Previous managerial experience directly managing people and/or experience in leading teams, projects, programs or directing the allocation of resources

Preferred Qualifications

  • Solid knowledge of downstream, as well as a general knowledge of the associated analytical, and buffer preparation techniques

  • Energetic and technically-minded, with strong interpersonal and organizational skills

  • Demonstrate the ability to learn new systems and applications, and various purification techniques

  • Work effectively in team and/or project environments; possess strong math and computer skills, as well as the ability to apply science-based thinking to practical applications

  • Experience in cGMP production environment

  • Bachelor's degree in Biology, Chemistry, or Chemical/Biological Engineering (or other relevant field) and 1or more years of managerial experience in Life Sciences field

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent b

iotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.