Amgen Senior Associate Molecular/Cellular Biology and Safety Biomarkers in Cambridge, Massachusetts

As part of our commitment to bring safe and transformative medicines to patients, we are expanding our innovative Translational Systems Biology group at Amgen. Our mission is to ensure that the drugs we develop are safe for our patients. To achieve this, we are applying a variety of human-focused in vitro approaches including stem cell modelling, human genetics, and biomarker discovery to develop novel assays that can predict or elucidate mechanisms leading to drug safety issues. In addition to working broadly to support pipeline projects, we are also developing novel methodologies for assessing the safety of our drug targets in human systems with the long-term goal of being able to focus our future regulatory studies in this area.

We are seeking a talented and versatile Senior Associate with expertise in molecular biology and biochemistry, 'omics technologies and biomarker discovery/validation to join our group.

Key Responsibilities

  • Design, manage and perform wet lab experiments focused on biomarker discovery and assay development using targeted (e.g. ELISA, flow cytometry) and untargeted (various 'omics technologies e.g. metabolomics, proteomics or transcriptomics) approaches

  • Design and execute experiments focused on the molecular understanding of safety-relevant phenotypes and targets using a variety of platforms (e.g. biochemical and cellular assays)

  • Generate high quality data analysis, interpretation, accurate report and presentation

  • Investigate novel platforms and technologies that can contribute to understanding the biology underpinning drug safety

Basic Qualifications

Master's Degree or Master's degree completed by June 2018

OR

Bachelor's degree and 2 years of scientific experience

Preferred Qualifications

  • Master's degree in molecular or cellular biology, biochemistry with more than 2 years of scientific experience

  • Strong molecular biology and biochemistry skills including ddPCR/qPCR, ELISA, flow cytometry, Western blotting, etc.

  • Experience in performing 'omics experiments such as proteomics, genomics or transcriptomics

  • Familiarity with mammalian cell culture methods e.g. Human iPSC culture and gene editing

  • Proficient in analysis of large, quantitative data sets

  • Laboratory experience in biomarker discovery or assay development

  • Ability to work independently on experimental design and execution

  • Comfort in working in a highly interactive environment, keen learner with a passion for teamwork

  • Good written and verbal communication skills

  • Ability to follow lab protocols and regulations

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.