Amgen Scientist - Structural Biology in Cambridge, Massachusetts

Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is significantly expanding our Research and Development facility in Cambridge MA (AMA).

We are looking for a highly motivated and creative structural biologist to join the interdisciplinary AMA Structural Biology group. This laboratory provides comprehensive molecular insight and structure-based design for drug target assessment, mechanism of action, protein-protein and protein-ligand interactions, as well as protein engineering to facilitate drug discovery across all therapeutic areas at Amgen.

The successful candidate will have the opportunity to contribute directly to the exciting drug discovery process through structural studies on a wide variety of important biological systems, including human integral membrane proteins.

The candidate will be responsible for leading projects through the entire protein crystallographic and cryo-EM processes, including protein chemistry. The candidate will be working closely with molecular biologists and protein biochemists in the protein technology team. The candidate will also interact directly with both small molecule and large molecule project teams, including computational scientists, medicinal chemists, and protein engineers.

Basic Qualifications:

Doctorate degree

OR

Master's degree and 4 years of scientific experience

OR

Bachelor's degree and 6 years of scientific experience

Preferred Qualifications

PhD in protein biochemistry, crystallography, or related discipline with significant postdoctoral research experience

Knowledge of state-of-the-art protein structural biology techniques including all aspects of construct design, expression, purification, characterization, crystallization, structure determination and analysis

Experience with single particle cryo-EM process (including sample/grid preparation and screening, data collection and processing, three-dimensional reconstruction and model building)

Excellent presentation skills (written and oral) that enhance team-based progress

Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.